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Hearing loss and cancer treatments.

Physicians are well aware of the many side effects of chemotherapy and radiation treatment. However, only in recent years has research addressed the risk of hearing loss and related conditions (e.g. tinnitus) as reported by numerous post-cancer treatment patients. These studies have revealed a strong link between hearing loss and cancer treatments, especially among certain chemotherapy medications. It is important for both physician and patient to understand the risk of ototoxicity when treating cancer, and its long-term implications, which may include permanent hearing loss.

 Ototoxicity and its relationship to cancer treatments. Certain chemotherapy medications or radiation therapy can cause ototoxicity, which may be manifested as temporary or permanent hearing loss, depending on the type treatment and the extent of hearing damage.

Ototoxicity resulting in sensorineural hearing loss (SHL) refers to drug or chemical damage to the inner ear where cochlear hair cells vibrate in response to sound waves. This damage may affect vital hearing and balance information to the brain, resulting in hearing loss, tinnitus, and/or loss of balance.

Platinum-based chemotherapy medications, particularly cisplatin and carboplatin, are considered the primary “culprits” when it comes to ototoxicity. Other potentially ototoxic chemotherapy drugs include Bleomycin, Vincristine, Vinblastin, Bromocriptine, and Methotrexate Nitrogen mustard1.

Chemotherapy from the “platinum” group is frequently used to treat brain, head and neck cancers, as well as lung, bladder and ovarian cancers in adults. It is also commonly used to treat brain, bone and liver cancers in children.

Effects of ototoxicity in adults. • Physical effects of hearing loss including balance issues and a greater likelihood of falls2 over time, especially in older adults. Hearing loss has also been linked to the development of certain forms of dementia3 and cognitive decline.

  • Psychological fallout, including depression, isolation, anxiety, anger, and poor self-image4.
  • Economic impact, which includes higher rate of unemployment, difficulty retaining a job or advancing career5.

Because of the long-term effects of hearing loss in adult survivors, and the debilitating effects associated with the condition, oncologists will likely do their utmost to mitigate ototoxic exposure during treatment. When aggressive treatment is necessitated, and the patient experiences hearing loss, it is important to consider treatment options such as hearing aids, which can help 95% of patients with hearing loss. As cancer treatments have more success, and cancer patients live longer, hearing loss treatment, could improve the patient’s quality of life after cancer treatment.

“Twenty years ago, many patients considered themselves lucky to survive – now medical advances mean that quality of life after treatment is also crucial”6

Summary

Hearing loss can be a negative after-effect of certain chemotherapy medications and radiation therapy. While treatment is ongoing, an audiologist can assist with monitoring for ototoxicity and make recommendations for early intervention if possible. As medications improve, more treatment options become available, and survival rates continue to rise, the need for medical professionals to consider quality of life post-treatment becomes crucial. After treatment is complete, an audiologist should evaluate the patient for ototoxic after-effects and if necessary offer counseling, treatment – which could include hearing aids and rehabilitation.


1 American Tinnitus Association. Ototoxic Brochure by League for Hard of Hearing. 2012.

2 USNews.com. Hearing Loss Triples Risk of Falling: Study. 2012

3 Johns Hopkins Medicine. Hearing Loss Accelerates Brain Function Decline in Older Adults. 2013

4 Mary Kaland, Kate Salvatore. The Psychology of Hearing Loss. The ASHA Leader. 2002

5 David Jung, Neil Bhattacharyya. Association of Hearing Loss with Decreased Employment and Income Among Adults in the United States. Annals of Otology, Rhinology & Laryngology. 2014

6 Mark Downs, Executive Director of technology and Enterprise of the British RNID

7 Hear-it. Chemotherapy can cause hearing loss. Audiology Online; RNID. 2009

8 Johnnie K. Bass, Stephanie T. White, Skye E. Jones. Monitoring Ototoxicity in the Pediatric Oncology Population. American Speech-Language-Hearing Association. 2014

9 Oregon Health & Science University. “Hearing Loss From Chemotherapy Underestimated.” ScienceDaily. December 2005. <www.sciencedaily.com/releases/2005/12/051212164355.htm>. (link to http://www.sciencedaily.com/releases/2005/12/051212164355.htm/).